The document discusses aspartate aminotransferase (AST) and alanine aminotransferase (ALT) tests, which are liver enzymes. Elevated levels of AST and ALT indicate liver damage, as the liver releases these enzymes into the bloodstream when injured. Both AST and ALT levels are reliable for detecting liver disease issues like hepatitis, cirrhosis, and effects of medications on the liver. The ratio of AST to ALT can help determine if the liver specifically or another organ is the source of the damage.
The document discusses aspartate aminotransferase (AST) and alanine aminotransferase (ALT) tests, which are liver enzymes. Elevated levels of AST and ALT indicate liver damage, as the liver releases these enzymes into the bloodstream when injured. Both AST and ALT levels are reliable for detecting liver disease issues like hepatitis, cirrhosis, and effects of medications on the liver. The ratio of AST to ALT can help determine if the liver specifically or another organ is the source of the damage.
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The document discusses aspartate aminotransferase (AST) and alanine aminotransferase (ALT) tests, which are liver enzymes. Elevated levels of AST and ALT indicate liver damage, as the liver releases these enzymes into the bloodstream when injured. Both AST and ALT levels are reliable for detecting liver disease issues like hepatitis, cirrhosis, and effects of medications on the liver. The ratio of AST to ALT can help determine if the liver specifically or another organ is the source of the damage.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as PPT, PDF, TXT or read online from Scribd
a wide variety of tissues-including heart, skeletal
muscle, kidney, and brain in addition to liver. V Serum levels of AST and ALT are elevated to some extent in almost all liver diseases (viral hepatitis, obstructive jaundice and liver cirrhosis). V Serum levels of AST and ALT are elevated to some extent in almost all liver diseases (viral hepatitis, obstructive jaundice and liver cirrhosis). V An aspartate aminotransferase (AST) test measures the amount of this enzyme in the blood. AST is normally found in red blood cells, liver, heart, muscle tissue, pancreas, and kidneys. V Low levels of AST are normally found in the blood. When body tissue or an organ such as the heart or liver is diseased or damaged. After severe damage, AST levels rise in 6 to 10 hours and remain high for about 4 days V AST formerly was called serum glutamic oxaloacetic transaminase (SGOT). V An aspartate aminotransferase (AST) test is done to:
V Check for liver damage.
V Help identify liver disease, especially hepatitis and cirrhosis. Liver disease may produce symptoms such as pain in the upper abdomen, nausea, vomiting, and sometimes jaundice. V Check on the success of treatment for liver disease. V Find out whether jaundice was caused by a blood disorder or liver disease. V Keep track of the effects of cholesterol- lowering medicines and other medicines that can damage the liver. V The AST test may be done at the same time as a test for alanine aminotransferase, or ALT. The ratio of AST to ALT sometimes can help determine whether the liver or another organ has been damaged. Both ALT and AST levels can test for liver damage. V An alanine aminotransferase (ALT) test measures the amount of this enzyme in the blood. ALT is found mainly in the liver, but also in smaller amounts in the kidneys , heart , muscles, and pancreas V ALT is measured to see if the liver is damaged or diseased. Low levels of ALT are normally found in the blood. But when the liver is damaged or diseased, it releases ALT into the bloodstream, which makes ALT levels go up. Most increases in ALT levels are caused by liver damage. V ALT was formerly called serum glutamic pyruvic transaminase (SGPT). V The ALT test is often done along with other tests that check for liver damage, including aspartate aminotransferase (AST), alkaline phosphatase, lactate dehydrogenase (LDH), and bilirubin. Both ALT and AST levels are reliable tests for liver damage. V The alanine aminotransferase (ALT) test is done to:
V Identify liver disease,
especially cirrhosis and hepatitis caused by alcohol, drugs, or viruses. V Help check for liver damage. V Find out whether jaundice was caused by a blood disorder or liver disease. V Keep track of the effects of cholesterol- lowering medicines and other medicines that can damage the liver. °
1) The reference range for ALP is dependent on age.
2) In the human body, ALP has been identified
in liver, bone, intestine, kidney and leukocytes. ALPs are a heterogeneous group of enzymes. For patients with high ALP levels, measurement of ALP isoenzymes is useful for differentiating between bone and liver sources.
3) The highest elevations of ALP in patients
with liver disease occur in patients with cholestasis or hepatic carcinoma. V A test for alkaline phosphatase (ALP) is done to:
V Check for liver disease or damage to the liver.
Symptoms of liver disease can include jaundice, belly pain, nausea, and vomiting. An ALP test may also be used to check the liver when medicines that can damage the liver are taken. V Check bone problems (sometimes found on X- rays), such as rickets, osteomalacia, bone tumors, Paget's disease, or too much of the hormone that controls bone growth (parathyroid hormone). The ALP level can be used to check how well treatment for Paget's disease is working. V An indices of a blockage of bile flow Cholestasis, V which maybe intra- or extra-hepatic disease V (tumor, cirrhosis ) V ADULT 25~90U/L CHILD 50~350U/L