Recent Advances in

Homoeopathy

Dr. R. Valavan, BHMS, MD (Hom.Pharm)

Manager – Scientific Affairs
Dr. Willmar Schwabe India Pvt. Ltd.
Noida, UP
Recent Advances in Homoeopathic
Pharmacy can be Categorized into
 Homoeopathic Drug Manufacturing
 Manufacturing techniques
 Good Manufacturing Practices
 Advancements in Pharmacopoeias
 Quality Control
• Pharmacognosy
• Pharmaceutical Analysis
 Drug Proving (Homoeopathic Pathogenetic Trial)
 Basic Research
 Others
Homoeopathic Drug Manufacturing
Manufacturing Techniques
 Succussion – Manual
Homoeopathic Drug Manufacturing
Manufacturing Techniques

 Automatic Potentiser
Homoeopathic Drug Manufacturing
Manufacturing Techniques
 Manual Triturators
Homoeopathic Drug Manufacturing
Manufacturing Techniques
 Mechanical
Triturators
Homoeopathic Drug Manufacturing
Good Manufacturing Practices
 Location and surrounding
 Building and rooms
 Water quality
 Disposal of waste
 Container management
 Arrangement for personal cleanliness of workers
 Standard operating practices (SOPs)
 Testing
 Warehousing of materials
Homoeopathic Drug Manufacturing
Good Manufacturing Practices

 Epoxy flooring
 Air Handling Units (AHU) and High
Efficiency Particulate Air (HEPA) Filters
 Extra-neutral Alcohol (ENA)
Epoxy flooring
Advancements in Pharmacopoeias
 Uniform drug strength
 Introducing proper method to prepare
nosodes
 Particle size of 10 microns at 1x level
 Introducing modern methods of
standardisation like TLC and HPLC
 Recommending special and stringent
storage conditions for certain drugs
 Quality Control - Pharmacognosy
 Microscopical examination of plant drugs
 Anatomical study of drug material
 Various parts of herbal drugs
 Preliminary phyto-chemical screening
 Successive solvent extraction (Quantitative)
 Qualitative chemical examination
 Thin Layer Chromatography
 UV Spectroscopy
 HPLC
Passiflora – Microscopical
Examination
Sabina – Microscopical
Examination
 Quality Control - Pharmaceutical
Analysis
 Spectral methods
 Visible spectroscopy
 UV spectroscopy
 IR spectroscopy
 NMR spectroscopy
 Atomic absorption spectroscopy
 Chromatographic methods
 TLC, GC, HPLC, etc.
 Electro-chemical techniques
 Potentiometry
 Conductometry
 Polarography
 Titrimetry
Sabina - TLC
Salix alba, Salix nigra & Salix
purpurea - TLC
UV Spectroscopy
 Drug Proving (Pathogenetic Trial)

Methodological flaws in Hahnemannian Drug

provings & minimization strategies in modern
HPTs.
 Drug Proving (Pathogenetic Trial)
Methodological Consequences Minimization
flaws strategies
Absence of Overestimate of Use of
control groups medicine effects comparative
(random symptom + placebo group.
medicine symptom)
Use of well Overestimate of Use of non
known friends medicine effects subservient
as provers (placebo effect to provers +
please master placebo
prover) comparison)
Provers were Overestimate of Masked medicine
informed medicine effects & placebo group)
about (Expectancy +
medicine conditioning effect)
Recording all Overestimate of Keep pre-
symptoms & medicine effects observation period
signs. (Medicine symptoms + predefined
+ naturally occurring criteria for selection
symptoms) of pathogenetic
effect
Absence of Overestimate of Double masking of
masking medicine effects provers &
provers & (selective perception supervisors
supervisors + investigators
effect)
Close Overestimate of Moderate
supervision & medicine effects supervision &
daily recording of (Hawthorne effects) standard
symptoms questions
Sudden Overestimate of Observation of
prohibition of tea, medicine effects provers as usual.
coffee etc (effects of Definite exclusion
abstinence & criteria.
surfacing of hidden
symptoms)
Vague definition Overestimate of Definite inclusion
of healthy medicine effects & exclusion
provers (symptoms related criteria. Use of
to prior & current validated
disease) questionnaire
 Basic Research
Electromagnetic Signals Are Produced by
Aqueous Nanostructures Derived from
Bacterial DNA Sequences
 A novel property of DNA is described: the capacity of
some bacterial DNA sequences to induce
electromagnetic waves at high aqueous dilutions. It
appears to be a resonance phenomenon triggered by the
ambient electromagnetic background of very low
frequency waves. The genomic DNA of most pathogenic
bacteria contains sequences which are able to generate
such signals. This opens the way to the development of
highly sensitive detection system for chronic bacterial
infections in human and animal diseases.
 Basic Research
Electromagnetic Signals Are Produced by Aqueous
Nanostructures Derived from Bacterial DNA Sequences
…Contd…
 Pathogenic bacteria and viruses show a distinct EM
signature at dilutions ranging from 10(-5) to 10(-12)
(corresponding to 5X to 12X) and that small DNA fragments
(responsible for pathogenicity) were solely accountable for
the EM signal.
 EM signature changed with dilution levels but was
unaffected by the initial concentration and remained even
after the remaining DNA fragments were destroyed by
chemical agents.
 Ref.:Luc Montagnier, Jamal Aissa, Stéphane Ferris, Jean-Luc Montagnier, Claude Lavallee,
Electromagnetic Signals Are Produced by Aqueous Nanostructures Derived from Bacterial DNA
Sequences.  Interdiscip Sci Comput Life Sci (2009) 1: 81-90.
 Basic Research
Thermoluminescence of ultra-high dilutions of lithium
chloride and sodium chloride
 Ultra-high dilutions of lithium chloride and sodium
chloride (10−30 g cm−3) have been irradiated by X- and
γ- rays at 77 K, then progressively re-warmed to room
temperature. During that phase, their
thermoluminescence has been studied and it was found
that, despite their dilution beyond the Avogadro number,
the emitted light was specific of the original salts
dissolved initially.
 Rey Louis, “Thermoluminescence of Ultra – High Dilutions of Lithium Chloride and Sodium
Chloride”, Physica A, 2003; 323: 67-74. Available also in the web page:
www.vhan.nl/documents/Rey.thermoluminescence.pdf
 Basic Research
Study of Thyroxin in tadpoles
 The study of Thyroxin 30x in tadpoles (larval frog), has
showed the inhibition of growth of tadpoles. Also, when a
glass bottle containing Homoeopathic dilution of Thyroxin
hormone (30x) is suspended in the tank of tadpoles,
without any contact with the water, the growth of tadpoles
was inhibited. The research was replicated at several
laboratories with consistency in results. The implications of
this study are significant, in showing that Homoeopathic
medicines have some type of radiational effect through
glass. This radiational effect may be tested with various
homoeopathic medicines and the results recorded for
further studies.
 Endler. P.C., Pongratz. W., Smith. C.W. et al., “Non-Molecular Information Transfer From
Thyroxine to Frogs”, available in the web page: www.giriweb.com/endler.htm
 Basic Research
Study with dexamethasone
 The interaction of dexamethasone 10−17 and 10−33 M (equivalent to 7CH and 15CH)
with dexamethasone in pharmacological concentrations was evaluated, using as
experimental models: acute inflammation induced by carrageenan.
 Animals were treated with the following preparations: (1) phosphate buffer saline
(PBS) solution; (2) dexamethasone (0.5 mg/kg for inflammation model or 4 mg/kg
for tumour model) mixed with dexamethasone 7CH or 15CH; (3) dexamethasone
(same doses) mixed in PBS.
 Homoeopathic dexamethasone partially blocked the anti-inflammatory effect
of pharmacological dexamethasone with regard to paw oedema (two-way
ANOVA, P≤0.0008) and polymorphonuclear cell migration (χ2, P=0.0001).
 Potentised dexamethasone restored control levels of tumour infiltrating leucocytes
(TIL) viability, compared to mice treated with pharmacological doses of
dexamethasone (χ2, P≤0.001).
 The results demonstrate that a potentised substance may change its own
pharmacological effects and suggest that ultradilutions effects act mostly on
host response.
 LV Bonamin, KS Martinho, AL Nina, F Caviglia and RGW Do Rio, Very high dilutions of dexamethasone inhibit its
pharmacological effects in vivo, British Homoeopathic journal, Volume 90, Issue 4, October 2001, Pages 198-203
 Basic Research
Ultra low dose aspirin on platelet activity in portal hypertension
 This study aimed to investigate the mechanism involved in the potentially beneficial
effect of ultra low dose aspirin (ULDA) in prehepatic portal hypertension.
 Rats were pretreated with selective COX (Cyclooxygenase) 1 or 2 inhibitors (SC-560
or NS-398 respectively), and subsequently injected with ULDA or placebo. The ULDA
was prepared similar to homoeopathic preparation and the dilution used was
equivalent to 15C or 30X.
 Results: The portal hypertensive group receiving a placebo showed a decreased in
vivo platelet activity with prolonged IHT (induced haemorrhagic time), an effect that
was normalized by ULDA. SC-560 induced a mild antithrombotic effect in the normal
rats, and an unmodified effect of ULDA. NS-398 had a mild prothrombotic action in
portal hypertensive rats, similar to ULDA, but inhibited a further effect when ULDA
was added. An increased 6-keto-PGF1α was observed in portal hypertensive group
that was normalised after ULDA administration
 Results suggest that the effect of ULDA on platelet activity in portal hypertensive rats,
could act through a COX 2 pathway more than the COX 1, predominant for aspirin at
higher doses.
 Ref.:Francisco X Eizayaga, Omar Aguejouf, Vanessa Desplat, et al., Modifications produced by selective
inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension, World J
Gastroenterol 2007 October 14; 13(38): 5065-5070
 Basic Research
Histamine dilutions and basophil activation
 Many such studies have been carried out on stimulating
the basophil by highly diluted Histamine. Histamine is
known to elicit a negative feedback effect on anti-IgE
and allergen-induced basophil activation. A series of
experiments performed between 1981 and 1995 using a
manual method showed biological activity of highly
diluted histamine. J. Benveniste’s work on this is
significant. Most of the experiments used histamine in
the range 10−30 (15C)–10−36 M (18C). These results
were confirmed by automated flow cytometry. This
method is based on the selection of basophils by anti-IgE
and analysis of basophil activation by anti-CD 63.
 Others
 International Journals
 Online Resources
 Homoeopathic Softwares
 Homoeopathic Radio
 International Journals
 Homeopathy (Formerly British Homoeopathic Journal)
http://www.sciencedirect.com/science/journal/14754916
 The Journal of Alternative and Complementary Medicine http://
www.liebertpub.com/products/product.aspx?pid=26
 Internation Journal of High Dilution Research http://
www.feg.unesp.br/~ojs/index.php/ijhdr/index
 Physica A http://www.sciencedirect.com/science/journal/03784371
 American Journal of Homoeopathic Medicine
http://www.homeopathyusa.org/journal
 Homoeopathic Links
 Indian Journal of Research in Homoeopathy http://ccrhindia.org/ijrh.asp
 Asian Journal of Homoeopathy
Email : homoeomag@yahoo.com
 Online Resources
Homoeopathic
 http://homeoint.org
 www.hpathy.com
 http://www.homeopathic.com
 http://www.similima.com
 http://www.homeopathyhome.com
 Online Resources
Medical
 MedlinePlus
 http://www.nlm.nih.gov/medlineplus/encyclopedia.html
 Mayo Clinic
 http://www.mayoclinic.com
 Merck
 http://www.merck.com
 Wikipedia
 http://www.wikipedia.org
 http://en.wikipedia.org/wiki/Main_Page
 Homoeopathic Radio
 Homoeopathy radio station
 www.vitalforceradio.com
 Homoeopathic Softwares

Advantages
 Repertorisation made easy
 Case taking made easy
 Record keeping made easy
 Online case records
 Homoeopathic Softwares
 Radar
 Hompath
 OpenRep
 MacRepertory
 Kenbo
 ISIS
 Mercurius
 Vital Quest – Case taking software
 Doctor24x7
 RADAR
 RADAR is an acronym of Rapid Aid
to Drug Aimed Research
 It has mainly 3 components
 RADAR
• Repertory systems an analysis
• Expert system
• Concept and themes
 Encyclopaedia Homoeopathica (EH)
• Materia medica
• Reference
 Winchip
• Patient register
 Kenbo
• Case taking software
 Conclusion

 More advancements are to be brought into

the field of homoeopathy.
 Conclusion
It is our responsibility to
conduct researches as
many as possible and bring
up more advancements in
homoeopathy in general
and homoeopathic
pharmacy in particular
THANK YOU