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rate (MCR)
Defines the quantitative removal of hormone
from plasma
The bulk of hormone is cleared by liver and
kidneys
Only a small fraction is removed by target
tissue
protein and amine hormones bind to receptors and
are internalized and degraded
Steroid and thyroid hormones are degraded after
hormone-receptor complex binds to nuclear
chromatin
MC R of so me h ormo nes
Hormone Half-life
ACTH
Cell s urfa ce r eceptor actio n
G-p rotein c ouple d
recepto rs
Adenylate cyclase, cAMP and PKA
Amplification
via 2nd
messenger
Tr ansme mbrane
kin ase -li nked
recepto rs
Certain receptors have intrinsic kinase activity.
These include receptors for growth factors, insulin
etc.
Type I Diabetes
Me chanism s of
endocrine dise ase
Deficiency can also arise from genetic
defects in hormone production—gene
deletion or mutation, failure to cleave
precursor, specific enzymatic defect
(steroid or thyroid hormones)
Grave’s Disease
Me chanism s of
endocrine dise ase
Alterations in receptor number and
function result in endocrine disorders
Most commonly, an irregular increase in
the level of a specific hormone will cause
a decrease in available receptors
Type II diabetes
Various types of abnormal secretion of a target organ hormone (TOH), which is
normally regulated by a tropic hormone (TH) from the anterior pituitary. Bold and
broken lines depict greater and less than normal rates of secretion, respectively. Cross-
hatching indicates the location of the defect. Simulation and inhibition are indicated by
(+) and (-), respectively.
Hy pot hal am us
and P itu it ar y
Hyp oth ala mu s and
Pitu itary
The hypothalamus-pituitary unit is the
most dominant portion of the entire
endocrine system.
The output of the hypothalamus-pituitary
unit regulates the function of the thyroid,
adrenal and reproductive glands and also
controls somatic growth, lactation, milk
secretion and water metabolism.
Hypothal amus and
pi tui tary gl and
Hypothal amus and
pi tui tary gl and
Hypothala mu s and
Pit uitary
Pituitary function depends on the
hypothalamus and the anatomical organization
of the hypothalamus-pituitary unit reflects this
relationship.
The pituitary gland lies in a pocket of bone at
the base of the brain, just below the
hypothalamus to which it is connected by a
stalk containing nerve fibers and blood vessels.
The pituitary is composed to two lobes--
anterior and posterior
Po st erio r Pituita ry:
neuro hyp ophysis
Posterior pituitary: an outgrowth of the
hypothalamus composed of neural
tissue.
Hypothalamic neurons pass through the
neural stalk and end in the posterior
pituitary.
The upper portion of the neural stalk
extends into the hypothalamus and is
called the median eminence.
Hypothal amus
and posteri or
pi tui tary
Midsagital view
illustrates that
magnocellular
neurons
paraventricular and
supraoptic nuclei
secrete oxytocin and
vasopressin directly
into capillaries in the
posterior lobe
An terio r pituit ary:
adenohyp ophysis
Anterior pituitary: connected to the
hypothalamus by the superior hypophyseal
artery.
The antererior pituitary is an amalgam of
hormone producing glandular cells.
The anterior pituitary produces six peptide
hormones:
prolactin, (PRL)
growth hormone (GH),
thyroid stimulating hormone (TSH),
adrenocorticotropic hormone (ACTH),
follicle-stimulating hormone (FSH),
and luteinizing hormone (LH).
Hypothal amu
s and
anteri or
pi tui tary
neurosecretory
cells secrete
releasing factors
into capillaries of
the pituitary portal
system at the
median eminence
which are then
transported to the
TSH
anterior pituitary
gland to regulate
LH
the secretion of
FSH
pituitary
hormones.
Anatomi cal and
functi onal or ga niz ati on
neocortex
Reticular
Thalamus Limbic
Regula tion
activating Optical
substance system system
pain Emotion, fright,
Sleep/ rage, smell vision
of
wake
Hyp othalam
(temperature) regulation regulation
(hunger, (blood pressure
BMI) etc)
us
Water balance (blood
Metabolic rate, stress
volume, intake--thirst,
response, growth,
output—urine volume)
reproduction, lactation)
Anterior
pituitary
posterior hormones
pituitary
hormones
Hypot halamus/ Pi
tu itary Axis
Posterior Pituitary
Hyp othalamic releas ing
factor s fo r anter ior pit uit ary
hormo nes