Professional Documents
Culture Documents
by
Emmanuel R. de la Fuente, M.D.
Overview of Cell Injury
Essentially all body structures are organized such that they help
maintain the automaticity and continuity of life.
3. Definition
4. Lesions
- Etiology
- Pathogenesis
- Morphology
- Pathophysiology
- Clinical manifestations
- Outcome
How do we know the you understand
the concept?
• Recognize the important elements in
a case scenario
• Analyze the components of the
element
• Synthesizing or organizing these
elements into an acceptable hypothesis
External and Internal Stresses
Labile cells
Stable cells
Permanent cells
Mechanisms of Adaptation
• Increasing cellular activity
- size (hypertrophy)
- number (hyperplasia)
• Decreasing cellular activity (atrophy)
• Altering cellular structure (metaplasia)
May be physiological or
pathological
Morphologic Expressions of Cell Adaptation
Hypertrophy
- increase in cell and organ size
- increase nuclear DNA and cytoplasmic organelles
Morphologic Expressions of Cell Adaptation
Hypertrophy
- increase in cell and organ size
- increase nuclear DNA and cytoplasmic organelles
Hypertrophy
Hyperplasia
Homeostasis
Atrophy
Homeostasis Disturbed
Atrophy
Homeostasis Disturbed Hypertrophy
Homeostasis Disturbed Hyperplasia
Homeostasis Disturbed Hyperplasia + Hypertrophy
Homeostasis Disturbed
Metaplasia
Homeostasis Restored
Adaptive
or reversible
change may be
irreversible
Control Mechanisms of Adaptation
Dysplasia or Neoplasia
Control Mechanisms of Adaptation
• Limits of adaptation
- growth factors
- epidermal growth factor
- platelet-derived growth factor
- insulin-like growth factor
- suppressor factors
- contact inhibition
- suppressor factors
Cell Injury and Cell Death
Primary targets
• Cell membrane
• Mitochondria
• Cytoskeleton
• Cellular DNA
Ischemia as a
cause of necrosis
General Biochemical Mechanisms
• Fatty change
1. Pigments
- Carbon
- Hemosiderin
- Bilirubin
- Lipofuscin
- Melanin
2. Proteins
3. Carbohydrates
Hemosiderin