INTRODUCTION

• Flavonoids are subclass of Polyphenols

• Consist of two Aromatic rings, each
containing atleast one –OH group, which
are connected through a 3-C bridge and
become a part of six-member heterocyclic
ring.
• Many of them occur as large molecules
called Tannins
GENERAL STRUCTURE
• For most food flavonoids
R4 =H, R5 =OH & R6 =H
• Expectations include
 Biochanin A; R4 =CH3
 Formonetin; R4 =CH3; R5
=R6 =H
 Glycitein; R5 =H; R6
=OH
 Hespritin; R4 =CH3
 OCCURANCE & DISTRIBUTION
• COLOUR RULES
• MAKE TEA TIME ANYTIME
• KICK IT UP WITH SPICE
• SLIP IN SOME SOY
• GO NUTS BUT DON’T GO CRAZY
• INVITE A GRAPE TO DINNER
 BIOSYNTHESIS
• Phe forms 4-Hydroxy Coumaroyl CoA in
presence of enzymes Phe lyase &
Cinnamic acid hydroxylase & combines
with Malonyl CoA to form Chalcone &
other Flavonoids
• Six major flavonoids in plants include
Chalcones, Flavones, Flavonols,
Anthocyanins & Condensed Tannins
 BIOAVAILABILITY &
METABOLISM
• Defined Operationally & pharmacologically
as proportion of compound administered IV that
appears in plasma over time when it is
administered orally.
• Isoflavones & Flavonoids may be rapidly &
predominately Glucoronidated in GI mucosa
• Phenolics are probably rapidly conjugated by
UDP-glucoronosyltransferases &/or
Sulfotransferases
 BIOACTIVITY OF FLAVONOIDS
• Wide spectrum of biological activity
• Antioxidant property is the most important from
therapeutical point of view
• From Pharmacological point of view inhibition of
Cyclooxygenase & Lipoxygenase as well as
scavenging of superoxide anions seem to be
essential
• Flavonoids also possesses Anti-inflammatory,
Anti-thrombic & Anti-aggregatory effects
POTENTIAL MECHANISMS FOR
INHIBITION OF CANCER
• ESTROGENIC & ANTI ESTROGENIC
ACTIVITY
• ANTIPROLIFERATIVE ACTION
• CELL CYCLE ARREST & APOPTOSIS
• ANTIOXIDATION
• INDUCTION OF DETOXIFICATION
ENZYMES
• REGULATION OF HOST IMMUNE
FUNCTION
 OTHER PHARMACOLOGICAL
ACTIONS
• Anti-toxic Effects
• Hepatoprotective Effects
• Cytoprotective Effects
• Anti-Viral Effects
• Genetic Effects in Mammalian Cells
• Effects on Multi Drug Resistance
 ADVERSE REACTIONS OF
FLAVONOIDS
• HEMOLYTIC ANEMIA
• ALLERGENCY
• TOXICITY
• LIFE SPAN SHORTENING
ANTIOXIDANT ACTIVITY
 VARIOUS FLAVONOIDS
PREPARATIONS IN WORLD
MARKET
• NATURAL CITRUS BIO-
FLAVONOIDS WITH ROSE
HIPS 120ml

INGREDIENTS
• Extract of rose hips,
• with a base of triple
filtered water,
• coconut glycerin,
• 12.15% alcohol
 IMPORTANCE OF SOME
NATURAL FLAVONOIDS
• Citrus Flavonoids,
particularly
Polymethoxylated
Flavones (PMFs)
possesses Anti-
inflammatory actions
in animals
• Improves Arthritis
symptoms
• Provide Antioxidant
protection
 VALERIAN
• Improves sleep quality
without morning
grogginess
• Mild, safer & non
addictive Sedative
• Sedative action aids in
anxiety, stress &
insomnia
• Primary chemical
constituents includes
Alkaloids, Valerenic acid,
Caffeic acid, Tannin &
Choline.
 PASSION FLOWER
• Primary chemical constituents
includes Alkaloids, Flavonoids
(Apigenin, Luteolin, Quercitin,
rutin), Flavone glycosides
• Induces Relaxation, Sleep &
Anti-Anxiety effects
• Non Addictive
• Recommended in
Cardiovascular Neurosis,
Bronchial Asthama, Coronary
diseases, sleep disorders
• Topically applied for Swollen
eyes, burns & skin irritations
 COCOA FLAVONOIDS
• Helps in treating
Diabetes, strokes,
vascular disease &
immune health
• Anti oxidants in Cocoa
(flavonoids) relaxes blood
vessels helping to lower
the blood pressure
• Treats Demnesia &
strokes
• Has Anti-inflammatory &
immune system
modulation effects
THANK YOU