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Bio lo g y
Chemistry
Cla ssific atio n o f
Ma tter
Elements
pure substances made of only one type of atom
Compounds
pure substances made of two or more different
elements
Elements Compounds
Oxygen Dihydrogen oxide (H2O)
Sodium Sodium chloride (NaCl)
Lead Lead nitrate
2.1
???
The remaining
elements may are
also essential to life,
but in small quantity
2.2
De fic ie ncie s in
esse ntia l ele ments
Normal crop Abnormal growth
Goiter
Atomic number
238
Chemical symbol U
92
Chemical name
Atomic Mass
2.4
Th e Pe rio dic Ta ble
Atomic number = the number of protons
1. Atomic # = 92 = protons
238 P N e
U
92
3. Mass # = 238
92 146 92
5. Neutrons = 238-92
N 7/7/7
-1
Cl 17/18/18
+1
Na 11/12/10
Iso topes
Isotopes have the same number of protons and
electrons, but different numbers of neutrons
Isotopes of Carbon
12 14
6 C 6 C
2.6
Usin g i soto pes i n
rese arch
Radioactive tracers
The radioisotope are used to replace normal atoms
in a molecule
The radioisotopes can then be traced using a
scintillation counter
Radiocarbon dating
Over time carbon 12 decays into carbon 14. The
amount of carbon 14 present in a fossil is a relative
estimate of its age.
Useful up to ~50,000 years
2.7
Usin g Radioactiv e T racers
APPLICATION Scientists use radioactive isotopes to label certain chemical
substances, creating tracers that can be used to follow a metabolic process or
locate the substance within an organism. In this example, radioactive tracers
are being used to determine the effect of temperature on the rate at which
cells make copies of their DNA.
Ingredients including
TECHNIQUE Radioactive tracer
(bright blue) Incubators
Ingredients for 1 2 3
1 making DNA are 10°C 15°C 20°C
added to human cells. One Human cells
4 5 6
ingredient is labeled with 3H, a 25°C 30°C 35°C
radioactive isotope of hydrogen. Nine dishes of cells
7 8 9
are incubated at different temperatures. The cells 40°C 45°C 50°C
make new DNA, incorporating the radioactive tracer
with 3H.
RESULTS The frequency of flashes, which is recorded as counts per minute, is proportional to the
amount of the radioactive tracer present, indicating the amount of new DNA. In this experiment, when
the counts per minute are plotted against temperature, it is clear that temperature affects the rate of
DNA synthesis—the most DNA was made at 35°C.
Optimum
30 temperature
Counts per minute
for DNA
synthesis
(x 1,000)
20
10
0
10 20 30 40 50
Temperature (°C)
2.7
Usin g Radioactiv e T racers
98
Post. Ant.
43 Tc
Metastatic Bone Carcinoma 2.7
Ele ctrons a nd e nergy
Valence electrons
Are those in the outermost, or valence shell
Determine the chemical behavior of an atom
2.9
Ele ctron Sh ell
Dia grams
Helium
Hydrogen 2 Atomic number
2He
He
1H
Atomic mass 4.00 Element symbol
First Electron-shell
2 e’s shell diagram
Second
8 e’s shell
Third
18 e’s shell
2.10
Val ence El ectr ons and
Chem ical Propert ies
2.9
Lewi s ( electron) Dot
Formu la s
H O H
???
N F
H 2O Cl 2
Co va le nt Bo nds
1 In each hydrogen
atom, the single electron
is held in its orbital by + +
its attraction to the
proton in the nucleus.
Hydrogen (H2).
Two hydrogen
H H
atoms can form a
single bond.
Oxygen (O2).
Two oxygen atoms
share two pairs of O O
electrons to form
a double bond.
Water (H2O).
Two hydrogen
atoms and one O H
oxygen atom are
joined by covalent H
bonds to produce a
molecule of water.
Methane (CH4).
Four hydrogen
atoms can satisfy H
the valence of
one carbon
H C H
atom, forming
methane.
H
Po la r v s. No n-p olar
Electronegativity
Is the attraction of an atom for the electrons in a
covalent bond
The more electronegative an atom
The more strongly it pulls shared electrons
toward itself
In a Non-polar Covalent Bond
The atoms have similar electronegativities
Share the electron equally
2.11
Highly e le ctronegat ive
at oms
Fluorine
Oxygen
Chlorine
Nitrogen
Po la r Co va le nt Bonds
In a polar covalent bond
The atoms have differing electronegativities
Electrons are shared unequally
Because oxygen (O) is more electronegative than hydrogen (H),
shared electrons are pulled more toward oxygen.
δ–
This results in a
partial negative
charge on the
oxygen and a
partial positive
O charge on
the hydrogens.
H H
δ+ δ+
H2O 2.11
Weak Bo nds
Hydrogen bonds
Form when a hydrogen atom bonded to one
electronegative atom is attracted to another
electronegative atom δ– δ+
Water H
(H2O) O A hydrogen
bond results
from the
H attraction
between the
δ+ partial positive
charge on the
δ–
hydrogen atom
of water and
Ammonia the partial
(NH3) N negative charge
on the nitrogen
H H atom of
δ+ H δ+ ammonia.
2.13
δ+
Weak Bo nds
Van der Waals interactions
Occur when temporarily positive and negative
regions of molecules attract each other
2.13
Weak b onds are
esse ntia l
Weak chemical bonds
Reinforce the shapes of large molecules
Help molecules adhere to each other
2.13
Ionic Bonds
Electron transfer between two atoms
creates ions
Ions
Are atoms with more or fewer electrons
than usual Cl
-1
+ –
Na Cl Na Cl
Na+ Cl–
Na Cl
Sodium on Chloride ion
Sodium atom Chlorine atom
(an uncharged (an uncharged (a cation) (an anion)
atom) atom)
2.15
Mo lecula r shape and
function Carbon Nitrogen
Natural
Binding to endorphin
endorphin Morphine
receptors
Endorphin receptors on the
surface of a brain cell
recognize and can bind to
both endorphin and Endorphin
morphine. Brain cell
receptors
2.15
Th e Formatio n of
Bo nds w ith Ca rbon
Carbon has four valence electrons
This allows it to form four covalent bonds
with a variety of atoms
2.16
The bondin g ve rsati lit y of
carbon
Carbon forms many diverse molecules
H H
(b) Ethane
C2H6 H C C H
H H
(c) Ethene H H
C2H4 C C
(ethylene) H H
2.16
Versa til ity of Carbon
The electron configuration of carbon
Gives it covalent compatibility with many
different elements
Hydrogen Oxygen Nitrogen Carbon
(valence = 1) (valence = 2) (valence = 3) (valence = 4)
H O N C
2.16
Car bon S kele ton Var iation
Carbon chains
Form the skeletons of most organic molecules
Vary in length and shape
H H H H H
(a) Length H C C H H C C C H
H H H H H
Ethane Propane
H
H C H
H H H H H H
(b) Branching H C C C C H H C C C H
H H H H H H H
Butane Isobutane
H H H H H H
H H
(c) Double bonds H C C C C H H C C C C H
H H H H
1-Butene 2-Butene
H H H
H C H
(d) Rings H C C H H C C H
H H C
H C C H
C C C
2.16
Cyclohexane Benzene
Functional Gr oups
Functional groups OH
CH3
Estradiol
Are the chemically
reactive groups of
atoms within an HO
organic molecule
Female lion
OH
Give organic Testosterone CH3
Male lion
2.17
Functional Gr oups
FUNCTIONAL HYDROXYL CARBONYL CARBOXYL
GROUP
O
C
OH O OH
NAME OF
Alcohols Ketones or Aldehydes Carboxylic Acids
COMPOUNDS
EXAMPLES
H H H O H O
H C C OH H C C H C C
H OH
H H H C H
Ethanol, the alcohol H
present in alcoholic H Acetic acid, which gives
beverages vinegar its sour tatste
Acetone, the simplest 2.17
ketone
Functional Gr oups
FUNCTIONAL
GROUP AMINO SULFHYDRYL PHOSPHATE
H O
N
O P OH
H SH OH
(may be written HS)
NAME OF
Amines Thiols Organic Phosphates
COMPOUNDS
EXAMPLES O H H H H OH OH H O
C C N H C C SH H C C C O P O−
HO H H H H H O−
H H
2.17