TISSUE REACTIONS TO INJURY

IMMUNE RESPONSE TO INJURY

Part 1: The Innate Immune Response
(Acute Inflammation)

Prepared by
EMMANUEL R. DE LA FUENTE, M.D.
 Objectives
2. Recognize the essential morphologic
features of acute inflammation, grossly
and microscopically
3. Briefly discuss the etiopathogenesis of the
different phases of acute inflammation
4. Correlate these lesions with the situational
events
 SITUATION NO. 1

A 12 year-old body complained of pain and

tenderness in the right iliac region. These
were accompanied by fever. An
appendectomy was performed.
CBC showed predominance of these leukocytes.
Describe this leukocyte and its role in the acute
inflammatory process.
Appendectomy specimen. Identify the lesion
and describe.
The next set of slides (1 to 5) shows the different
changes during the vascular, leukocytic, and
interstitial tissue phases of acute inflammation.
2. Identify and describe the changes in each slide
3. Indicate and describe the accompanying
interstitial tissue change, if present
4. Arrange these slides in chronological order
Slide 1
Slide 2
Slide 3
Slide 4
Slide 5
1. Briefly discuss the pathogenesis of each
lesion including the biomolecular aspects.
2. Discuss briefly the main chemical mediators
for each phase of the acute inflammatory
process
3. Correlate the lesions with the situational
events.
 SITUATION NO. 2
A 18 year-old female complaint of difficulty
of breathing accompanied by cough and
fever. Sputum culture revealed
Streptococcus pneumoniae.
Again, identify and describe the different events associated with
acute inflammation. In addition to the leukocytes, identify the
macrophages.
1. Discuss the process by which the
neutrophils and macrophages destroy
the offending organisms.
2. Discuss the possible consequences of
this lesion
The gross picture
illustrates a common
consequence of this
lesion. Identify and
describe.
This is the microscopic of the previous gross lesion. Describe
and discuss the pathogenesis of this lesion. Discuss the
pathogenesis of the two structures indicated by the arrows.
The arrow indicates a
gross morphologic
pattern of inflammation.
The picture illustrates a gross morphologic pattern of
inflammation. Identify and describe the lesion. Indicate also
the other evidences of acute inflammation. Discuss the
pathogenesis of the lesion,.
In most all instances, healing occurs through the formation
of granulation tissue as seen below. Identify the cells that
participate in granulation tissue formation and discuss their
respective roles.
1.Discuss the process of healing
2.Discuss the factors that influence
healing
Identify the type of healing that occurred in this
tissue. Explain why this type of healing.
This is the liver. Identify the type of healing. Explain.
This is the microcopy of the liver. Describe the two
processes of healing that can be seen in this section.
HEALING CAN ALWAYS OCCUR
AFTER INJURY AND DEATH.