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Human homeostasis is an internal equilibrium or balance system that monitors and regulates the complex functions of the body, ensuring that a normal state is maintained.
Figure 4. The glucose\fatty acid cycle well fed state BRAIN CO2 GLC PANCREAS
ADIPOSE TISSUE
Pyruvate
TG FA insulin [3]
Glucose + insulin
BLOOD
Insulin
KETONE BODIES
+ GLC
GLUCOSE (diet)
+ insulin GLC
CO2
LIVER MUSCLE
Role of GIT.
Role of liver. Role of kidneys. Role of Adipose tissue. Role of skletal muscles.
Insulin (Hypoglcemic)
Antiinsulin ( Hyperglycemic)
-Glucagon -Epinephrine -Glucocorticoids -Growth hormone -Thyroid hormones
A- Insulin: *It is secreted by the -cells of pancreatic islets in response to hyperglycemia. *It produces its effects through the following mechanisms:- It increases the uptake of glucose in muscles and adipose tissue. - It increases utilization of glucose (oxidation, glycogenesis and lipogenesis) in different tissues. - It decreases output of glucose by liver (decreases glycogenolysis and gluconeogenesis).
B- Anti-Insulin hormones (counter regulatory hormones): 1. Glucagon: * It is produced by a-cells of pancreatic islets.
* Its secretion is increased by fasting or any drop in blood glucose. Acts through formation of cAMP, leading to increased glycogenolysis and gluconeogenesis.
2. Epinephrine: ( hyperglycemic) Produced by adrenal medulla and secreted in large amounts in cases of stress, trauma, severe exercise, hypoxia, anesthesia (emergency hormone). - It increases glycogenolysis (through cAMP) in liver and muscles and inhibits glycogenesis. - It increases F.A. release and oxidation. - It decreases the uptake of glucose by the tissues. Increased secretion of adrenaline can produce D.M. (emotional or stress D.M.)
3. Cortisol:
Secreted by the adrenal cortex. - It stimulates protein catabolism, and gluconeogenesis from amino acids. - In extrahepatic tissues, it decreases glucose utilization.
Thyroxine
(+) insulin secretion. (+)insulin catabolism
Insulin
Stimulus for release Hyperglycemia.
Glucagon
Hypoglycemia.
I-GLC consumption
i-GLC entry (+) in adipose T., muscle.liver hhh Induces & activates (glucokinase, PFK1, PK ) Activates PDH Induces G6PDH # ,,, uptake # ,,, uptake ,,, uptake (in mus.)
PDH HMS
Insulin
iii-storage: glycogenesis Induces & Activates Glycogen synthase.
Glucagon
Epinephrine
Cortisol G.H.
II-GLC production
(-)
(+)
Activates liver glycogen phosphoryla se (not mus.) Induces 4 key enzymes
(+)
Activates liver & muscle glycogen phosphoryl ase. Induces 4 key enzymes
(+)
(+)
iGlycogenolysis Inactivates glycogen phosphorylase (dephosphorylat ion) ii-Gluconeogenesis Represses 4 key enz (PC,
PEPCK, F1,6 diphosphatase, G-6 phosphatase)
Insulin
iii-storage: glycogenesis Induces & Activates Glycogen synthase.
Glucagon
Epinephrine
Cortisol G.H.
II-GLC production
(-)
(+)
Activates liver glycogen phosphoryla se (not mus.) Induces 4 key enzymes
(+)
Activates liver & muscle glycogen phosphoryl ase. Induces 4 key enzymes
(+)
(+)
iGlycogenolysis Inactivates glycogen phosphorylase (dephosphorylat ion) ii-Gluconeogenesis Represses 4 key enz (PC,
PEPCK, F1,6 diphosphatase, G-6 phosphatase)
Insulin
Lipid metabolism:
I- lipogenesis
G.H.
(+)
II-lipolysis
(-)
no glycerol no excess FA
(+)
(+)
(+)
(+)
(+)
(-)
(+)
Releases a.a. Activates transaminases.
(+)
Induces liver transaminases
Insulin
I-GLC consumption:
GLC entry & GLC utilization & storage: II-GLC output: Glycogenolysis & gluconeogenesis.
G.H.
(+)
(-)
(-)
(-)
(-)
(-)
(+)
(+)
(+)
(+)
Net effect
Hypoglycemic hormone
Hyperglycemic Hormone
Hyperglycemic Hormone
Hyperglycemic Hormone
Hyperglycemic Hormone
,,,
hhh
hhh
hhh
hhh
Gastrointestinal tract regulates glucose level in blood by : a) Allows gradual absorbance and utilization of glucose. b) Allows sudden rise in glucose level in blood. c) The rate of glucose absorption is 10 mg/kg weight. d) Decrease insulin secretion.
Oral glucose stimulates insulin secretion more than I.V one because:
Regarding the role of the liver in glucose homeostasis , all the following are true Except : a) Liver is one of the most user of glucose in postabsorptive state. b) In fasting , the liver is the main producer of glucose. c) In postabsorptive state glycogenolysis is an active process. d) Glycolysis is an active process in postabsorptive state .
The Kidney has an important role in glucose homeostasis : a) It prevents the loss of glucose in urine whatever its blood level. b) It shares in supplying blood glucose during fasting state. c) It is the main user of glucose. d) It is responsible for excretion of glucose in physiological range.
All the following about epinephrine are true Except : a) It stimulates liver and muscle glycogenolysis. b) It stimulates lipolysis.
Which hormone lowers blood sugar levels by increasing the rate of entry of glucose into the cells? a. Growth hormone b. Glucagon c. adrenalin d. insulin
A person was admitted to the hospital with abnormally high blood sugar and an abnormally high sugar content in his urine. Which hormone is deficient in this person? a. Epinephrin b. Parathyroid hormone c. Glucagon d. Insulin
If a person consumes excess calories in the form of carbohydrates, what is the fate of the excess carbohydrates?
a. If glycogen stores are full, the carbohydrates are converted into amino acids. b. If glycogen stores are full, the carbohydrates are converted to fatty acids and stored as triacylglycerols. c. The carbohydrates are excreted without being metabolized. d. The carbohydrates are converted to ketone bodies to be utilized by the brain.
# Glucagon plays a homeostatic role in the body by A. facilitating glucose uptake into skeletal muscle. B. causing the activation of liver phosphorylase.
Write false or true in front of the following statements: a) Insulin is needed for glucose entry in liver. b) In carbohydrate deficiency, lipolysis is stimulated. c) Excess glucose is stored in adipose tissue as triglyceride. d) During fasting, , muscles oxidizes fatty acids for energy production.
- Free glucose released from muscle contributes significantly to the alleviation of hypoglycemia - Hepatic glycogenolysis is a primary source of blood glucose during a period of 48 h fasting.
GLYCOSURIA
Definition
Types:
1. Glucosuria
A- hyperglycemic glucosuria:
- D.M. - epinephrine glucosuria.
- alimentary glucosuria.
- experimental glucosuria.
GLYCOSURIA
B- Normoglycemic glucosuria:
2.
Fructosuria:
- alimentary fructosuria.
- essential fructosuria.
GLYCOSURIA
3. Galactosuria:
- alimentary galactosuria. - galactosemia. 4. Lactosuria.
Glucose concentration
Time in minutes