Professional Documents
Culture Documents
M. Cengiz YAKICIER
Sperm cell
Egg cell
Embyros cells with copies of Offspring with traits inherited DNA inherited from both parents
More than 200 cell types identified in human body Arranged into tissues - 4 basic tissue types
muscle
nervous tissue
germ cell - sperm red blood cells hair cell - sound receptor rod cells - photoreceptor cells
Binary Fission Prokaryotes (bacteria and archaea) reproduce by a type of cell division called binary fission In binary fission, the chromosome replicates (beginning at the origin of replication), and the two daughter chromosomes actively move apart
Origin of replication E. coli cell Chromosome replication begins. Soon thereafter, one copy of the origin moves rapidly toward the other end of the cell. Two copies of origin
Replication continues. One copy of the origin is now at each end of the cell.
Origin
Origin
Replication finishes. The plasma membrane grows inward, and new cell wall is deposited.
The Evolution of Mitosis Since prokaryotes evolved before eukaryotes, mitosis probably evolved from binary fission Certain protists exhibit types of cell division that seem intermediate between binary fission and mitosis
LE 12-12
Bacterial chromosome Prokaryotes Chromosomes Microtubules
Intact nuclear envelope Dinoflagellates Kinetochore microtubules Intact nuclear envelope Diatoms Kinetochore microtubules Centrosome Fragments of nuclear envelope
Most eukaryotes
Cellular levels of (mitotic) M-cyclin rises and falls during the cell cycle
M-cyclin levels are low during interphase but gradually increases to a peak level during mitosis M-cdk activity is, likewise, low in interphase but increases in mitosis
The abundance of cyclins (and the activity of Cdks) is regulated by protein degradation
M-cyclin becomes covalently modified by addition of multiple copies of ubiquitin at the end of mitosis Ubiqutination is mediated by the anaphase promoting complex (APC) Ubiquitination marks cyclins for destruction by large proteolytic machines called proteasome
Distinct cyclins partner with distinct Cdks to trigger different events of the cell cycle
S-Cdk triggers DNA replication - its destruction ensures this happens once per cell cycle
Cells can withdraw from the cell cycle and dismantle the regulatory machinery
G0 is a quiescent state Cdks and cyclins disappear Some cells enter G0 temporarily and divide infrequenty (I.e. hepatocytes) Other differentiated cell types (neurons) spend their life in G0
Developmentally-regulated apoptosis
Necrotic cell
Apoptotic cells
Necrosis
Apoptosis
Survival factors mediate essential cell death during formation of the nervous system