CiVentiChem (India) Private Limited

(Formerly Known as Indus BioSciences Private Limited)

Global operations in the USA and India with project management, 1 IP control and local solutions at our USA headquarters

Highlights of Presentation
History Business Overview Services and Capabilities Management Experience and Chemistry Expertise Chemistry Specialties & Capabilities Bulk Projects Performed in Plant Chemistry Experience
Examples in Med. Chem & P R&D

Proprietary Building Blocks

Facilities
Global operations in the USA and India with project management, 2 IP control and local solutions at our USA headquarters

History
1994 - Founded in RTP, North Carolina 1999 Expanded to Larger Laboratory 2000 Reached 12 Scientists at USA 2001 R&D Laboratories Opened in India with 5 Chemists 2009 Launch of our Plant in Hyderabad, India 2011 cGMP Synthesis lab in RTP, NC, USA
Global operations in the USA and India with project management, 3 IP control and local solutions at our USA headquarters

Business Overview
HQ: Services: People: Facilities: RTP, North Carolina Chemistry 80 Experienced Scientists & Admin USA and India
Discovery & Synthetic Chemistry, Process Development, Manufacturing & Analytical Services

RTP, North Carolina and Hyderabad, India 50,000 Sq Ft Total Technical Facilities

Customers: Around 150

including 10 of world Top 20 Pharma; 45 Biotechnology Companies.

Integrated Management Systems ISO-9001-2008 (QMS), 14001-2004 (EMS) and 18001-2007 (OSHA)

Global operations in the USA and India with project management, 4 IP control and local solutions at our USA headquarters

Our Role in Drug Development

Biological Target Screening Screening Hits Leads Drug candidate candidate Pre clinical Clinical Clinical Launch

Associated Chemistry

Screening Compounds

Parallel Synthesis

Medicinal Chemistry

Custom Synthesis

Process Scale - up

Pilot Plant

Manufacturing

CiVentiChem USA & Peakdale Molecular India

CiVentiChem CollaboratorsIndia

RESEARCH CHEMISTRY
Medicinal Chemistry Focused Libraries Reference Standards & Metabolites Lead Compounds & NCEs Lead Optimization Intermediates and Building Blocks available and in-stock

DEVELOPMENT CHEMISTRY

PRODUCTION CHEMISTRY

Rapid Initial Scale-up to first Kg Pilot Development Process Research & Manufacture Development Process Research & Feasibility Studies Development Pilot Development Manufacture Contract Manufacturing Manufacture Intermediatess & Manufacture Intermediates & APIs APIs cGMP &Global operations in the USA and India with project management, Non-GMP Protocols
IP control and local solutions at our USA headquarters
5

Global Advantages
Flexibility of Choice USA or India or BOTH !! Project Type Deadline Output Scale or Volume Research Requirements Expertise Requirements Communication and Project Control Lowest Cost
Global operations in the USA and India with project management, 6 IP control and local solutions at our USA headquarters

Business Overview - Clients

No. of clients 150 No. of Pharma Clients 10 (from world top 20 Pharma Companies) No. of Biotech Clients 10 + No. of Catalogue Companies 5 + No. of Fine Chemical Companies 10 +

Global operations in the USA and India with project management, 7 IP control and local solutions at our USA headquarters

Services and Capabilities

Global operations in the USA and India with project management, 8 IP control and local solutions at our USA headquarters

Research Chemistry Services

Medicinal Chemistry Synthesis of Focused Libraries & Analogues Synthesis of Reference Standards & Metabolites Synthesis of Lead Compounds & NCEs Lead Optimization & Parallel Synthesis Novel Template Molecules Ready for Purchase

Global operations in the USA and India with project management, 9 IP control and local solutions at our USA headquarters

Development/Manufacturing Services
Rapid Initial Scale-up to 1st Kilogram Route Scouting Process Development & Optimization Manufacture of Intermediates API ready starting materials
Global operations in the USA and India with project management, 10 IP control and local solutions at our USA headquarters

Management Experience

Global operations in the USA and India with project management, 11 IP control and local solutions at our USA headquarters

Management Team
Bhaskar Venepalli, Ph. D
Chief Executive Officer
Professional Experience

Vasu (Srinivas) Chittineni, Ph. D

Chief Technical Officer
Professional Experience

 25 + Years experience in fine chemicals including 13 20 + Years experience in synthetic organic Yrs experience in R&D, new product development & Business Management at Eastman Kodak-Eastman Chemical Company  Expertise in CRAMS & Fine Chemicals  Founder of Civentichem in 1994 in USA Education  Ph.D. from Osmania University, Hyderabad (IND) Post Doctoral Research at University of Education  Ph.D. from Kakatiya University (IICT, Hyderabad, INDIA)  Post Doctoral Research at Duke University , NC, USA
Global operations in the USA and India with project management, 12 IP control and local solutions at our USA headquarters

chemistry Expertise in Complex Organic Syntheses, Chiral & Carbohydrate Chemistry  Co founder of Civentichem in 1994

Southampton (England) & Rockefeller University, New York, (USA)

Management Team
Venkataiah Sunku, Ph. D Managing Director
Professional Experience  30 + Years experience in pharma including 8 Yrs experience as Director R&D at Aurobindo Pharma (India)  Expertise in Process Development & Plant Scale operations Developed processes for 22 bulk drugs & Transferred to Mfg Plants Education Education  Ph.D. in Chemistry from Osmania University, Hyderabad (INDIA).  6 Publications & Patents  Ph.D. in Chemistry from JNTUniversity (DRF, Hyderabad, INDIA)  25 Publications, Patents & Presentations
Global operations in the USA and India with project management, 13 IP control and local solutions at our USA headquarters

Venu (Venugopal) Veeramaneni, Ph. D Head R&D and BD&PM

Professional Experience 18 Years experience in Drug Discovery (Medicinal &Synthetic Organic Chemistry. Including 11 yrs at Dr. Reddys Discovery Research. Expertise in Synthesis of NMEs & Complex Organic Syntheses

Research Team @ Civentichem India

Hari Prasad Chittineni, Ph.D. Section Head, Process Development  14 Yrs Experience in Carbohydrate, Heterocyclic Chemistry including 4 Yrs in AVRA Synthesis  Expertise in Process Development M.Sc. From Osmania University Ph.D. from JNT University  7 Publications & Patents Venkat Laxman Rao Cilamkoti, Ph.D. Section Head, Medicinal Chemistry  16 Yrs experience in Multi Step Organic Synthesis including 8 Yrs in Dr Reddys Discovery Research  Expertise in Medicinal & Small scale Chemistry M.Sc. From Osmania University Ph.D. from Osaka University, Japan  9 Publications & Patents Shyam Group Leader 8 Yrs Exp in Med. Chem. & Small Scale M.Sc. from Osmania University RC Sekar Group Leader 8 Yrs Exp in Med. Chem. & Small Scale M.Sc. from Osmania University Rajitha Group Leader 8 Yrs Exp in New Building Blocks M.Sc. from Osmania University

Vineel, Vineel, Ph.D Group Leader 5 Yrs Exp in Sugar & Chiral Chemistry. Ph.D. from JUNTU

Mamatha Group Leader 8 Yrs Exp in Azaindole & Indazole Chemistry M.Sc. from Osmania University

Gopal Group Leader 8 Yrs Exp in Process & Scale Up Chemistry M.Sc. from Osmania University

Global operations in the USA and India with project management, 14 IP control and local solutions at our USA headquarters

Research Team @ Civentichem India

Venkataiah, Ph.D. MD

Global operations in the USA and India with project management, IP control and local solutions at our USA headquarters