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Facoltà di Ingegneria
MATHEMATICAL MODELING
OF BIOLOGICAL SYSTEMS
L’EPISCOPO GAETANO
MAZZARA BOLOGNA GIUSEPPE
Biological System
Physical Laws
Electrical Parameters
State-Space Transfer
Equations Function
RESISTANCE
Resistance Resistive and dissipative properties of system
V Potential
Ohm’s Law V
V=RI I R I Current
θ1 θ2
Fourier’s Thermal transfer law Δθ=RtQ Q
φ1 φ2
V
Capacitance Law V Potential
1
V = ∫ idt
C Current
I I
C
Also Capacitance Law can be generalized, applying it to other systems
ΔV
Fluidic Compliance law ΔV=CfΔP
ΔP
Inductance Law V
V Potential
dI
V =L L I Current
dt I
dv m F
F =m
dt
dQ R V P
= − ao Q − C + ao
dt Lao Lao Lao
dVC Q Pao
= −
dt Cao + C P Rao ( Cao + C P ) Pao input Q output
Q, VC State space variables
Transfer function:
Q S ( RP Cao + RPC P ) + 1
= 2
Pao S ( RPCao Lao + RPC P Lao ) + S ( Lao + Rao R p Cao + Rao RPC P ) + Rao + R P
Exercise 2: Equivalent electrical circuit of
Hodgkin-Huxley model of neuronal electrical
activity
C Membrane capacitance
Rk,Na,C1 Resistance of membrane to K,Na,C1
Ek,Na,C1 Nernst Potential of membrane for K,Na,C1
Exercise 2: Equivalent electrical circuit of
Hodgkin-Huxley model of neuronal electrical
activity
Equations are:
dV 1 1 1 E K E Na ECl
I =C
+ + +
V+ − +
dt RK RNa RCl RK RNa RCl
V + EK
IK =
RK
V − E Na
I Na =
RNa
V + ECl
I Cl =
RCl
Exercise 3: Analysis of the respiratory mechanics model
with effect of inertance to gas flow in central airways
RP RC, LC, CS
Cw
CL
Equations are:
dQ 1
Pao = RC Q + LC +
dt C S ∫ ( Q − Q ) dt A
1 1 1
RP QA + + ∫ QA dt =
C L CW CS ∫ ( Q − Q ) dt
A
d 2 Pao 1 dPao d 3Q LC d 2Q 1 RC dQ 1 1 1
2
+ = LC 3
+
RC +
2
+
+
+ + Q
dt RPCT dt dt RP CT dt CS RPCT dt R P CS CW CL
−1
1 1 1
Where: CT = + +
C
L CW C S
Exercise 3: Analysis of respiratory mechanics model
with effect of inertance to gas flow in central airways
Used Simulink model is:
Conclusions: Both inertance-complete model and neglecting-inertance one have quite similar
trends at all input frequencies. Emphysema model, instead, has a very different trend,
particularly at high frequencies; infact its peak-to-peak amplitude both for air flow and for air
volume is smaller as emphysema features outline.