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Manual of neonatal care 6th edition NEONATOLOGY: MANAGEMENT, PROCEDURES, ON-CALL
Definitions
-AGA, appropriate for gestational age: Birth weight
is between 10th and 90th percentile for infants gestational age (GA). percentile for GA. percentile for GA.
Other definitions: are sometimes used for SGA, including <3rd percentile
in expected fetal growth pattern. Multiple adverse conditions inhibit normal fetal growth potential. Not all IUGR infants are SGA.
growth-retarded fetuses.
Term infants with birth weights below the 3rd
percentile have higher morbidity and 10 times higher mortality than appropriate for gestational age infants.
McIntire DD et al: Birth weight in relation to morbidity and mortality among newborn
cause of IUGR.
An estimated 10% of cases are secondary to
congenital infection.
Chromosomal and other genetic disorders
California
CLINICAL SIGNIFICANCE:
Intrauterine growth retardation (IUGR)
higher for growth retarded infants, and morbidity is present in 50% of surviving infants.
Classification
Symmetricl
the baby's head and body are proportionately small. may occur when the foetus experiences a problem during early development.
Asymmetrical
baby's brain is disproportionally large when compared to the liver. may occur when the foetus experiences a problem during later development
In a normal infant, the brain weighs about three times more than the liver. In asymmetrical IUGR, the brain can weigh five or six times more than the liver.
Classification of IUGR
Symmetrical growth restriction: fetus whose
entire body is proportionally small. Incidence : 20 % Early gestational growth retardation would be expected to affect the fetus in a symmetric manner, and thus have permanent neurologic consequences for the infant. Examples of etiologies for symmetric growth retardation include genetic or chromosomal causes, early gestational intrauterine infections (TORCH) and maternal alcohol use.
Asymmetrical growth restriction: Decrease in
subcutaneous fat and abdominal circumference with relative sparing of head circumference and femur length. Incidence : 80 %
Aetiology
The foetal growth is dependent on multiple factors.
Aetiology
1. 2. 3. 4.
Maternal causes. Foetal causes. Placental causes. Idiopathic- In a majority of cases (40%) the cause is unknown probably due to placental insufficiency.
Has had a previous baby who suffered from IUGR. Extremes of age. Is small in size (Ht & Wt). Has poor weight gain and malnutrition during pregnancy. Is socially deprived. Uses substances (like tobacco, narcotics, alcohol) that can cause abnormal development or birth defects. Has a low total blood volume during early pregnancy.
Is pregnant with more than one baby. High altitude. Drugs like anticoagulants, anticonvulsants. Has a cardio-vascular diseasepreeclampsia, hypertension, cyanotic heart disease, cardiac disease, diabetic vascular lesions. Chronic kidney disease Chronic infection- UTI, Malaria, TB, genital infections Has an antibody problem that can make successful pregnancy difficult (antiphospholipid antibody syndrome, SLE).
etc).
A chromosome defect- trisomy-18 (Edwards syndrome),21(Downs syndrome), 16, 13, xo (turners syndrome). A primary disorder of bone or cartilage. A chronic lack of oxygen during development (hypoxia). Developed outside of the uterus. Placenta or umbilical cord defects.
Placental Factors
Uteroplacental insufficiency resulting from: Improper / inadequate trophoblastic invasion and placentation in the
first trimester.
Lateral insertion of placenta. Reduced maternal blood flow to the placental bed.
pregnancy.
Diagnosis
A. Establishing gestational age.
B. Fetal assessment
1. Clinical diagnosis. The patient's history
Ultrasonography. The following anthropomorphic measurements are used in combination to predict growth impairment with a high degree of accuracy.
When serial measurements of BPD are less than optimal, 50-80% of infants will have subnormal birth weights.
b. Abdominal circumference. The liver is the first organ to suffer the effects of growth retardation. Reduced abdominal circumference is the earliest sign of asymmetric growth retardation and diminished glycogen storage.
greater than the abdominal circumference. At about 32-36 weeks' gestation, the ratio is 1:1, and after 36 weeks the abdominal measurements become larger. Persistence of a head-abdomen ratio >=1 late in gestation is predictive of asymmetric IUGR.
d. Femur length.
Serial measurements of femur length are as effective as
suggests IUGR and fetal jeopardy, whereas normal placental morphology with a normal amount of amniotic fluid suggests a constitutionally small fetus.
indicate decreased uteroplacental perfusion. Fetal Doppler arterial waveform velocities indicate chronic fetal distress and hypoxia. Greatest risk is associated with absent or reversed diastolic flow in umbilical arteries.
C. Neonatal assessment
1. Reduced birth weight for gestational age is the simplest
Physical appearance. infections are excluded, the remaining group of IUGR infants have characteristic physical appearance.
because of loss of subcutaneous tissue, a scaphoid abdomen, and a disproportionately large head.
3. A ponderal index below the 10th percentile helps to identify
Childrens Hospital, Souraski Medical Center, University of Tel Aviv, Tel Aviv, Israel; Psychology Department, Developmental Neuropsychological Laboratory, Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel
intrauterine growth restriction on the neuropsychological profile and on academic achievements at 9 years of age using a largescale prospective paradigm.
STUDY DESIGN.
123 infants diagnosed with late-onset intrauterine growth
restriction were followed up yearly for 9 years. They were matched with 63 children for gestation age and multiple socioeconomic factors and evaluated by an extensive neuropsychological battery to assess intelligence quotient, academic achievements, learning and memory, visuomotor skills, visuospatial integration, attention, language, executive functions, and creativity.
RESULTS.
Children with intrauterine growth restriction had lower
intelligence quotient and more frequent neuropsychological difficulties. Difficulties in executive functioning, inflexibility-creativity, and language, indicative of frontal lobe dysfunction, were typically affected by intrauterine growth restriction and were rarely identified in the control group. Learning difficulties accompanied by lower academic achievements were more prevalent in the intrauterine growth restriction group, particularly when anthropometric catch-up was incomplete.
Maternal-Fetal Medicine
Neonatology Departments, Hospital Clinic CIBER-ER, University of Barcelona, Barcelona, Spain Fetal and Perinatal Research Group, August Pi i Sunyer Institute for Biomedical Research, Barcelona, Spain Department of Clinical and Health Psychology, Autonomous University of Barcelona, Barcelona, Spain
neurobehavioral outcomes of term, smallfor-gestational age (SGA) newborns with normal placental function.
METHODS
A cohort of consecutive term SGA newborns with normal prenatal umbilical artery Doppler ultrasound findings was created and compared with a group of term infants with size appropriate for gestational age, who were sampled from our general neonatal population.
for gestational age) were included. All of the neurobehavioral areas studied were poorer in the SGA group, with significance for attention, habituation, motor, social-interactive, and regulation of state.
CONCLUSION: Term SGA newborns with no signs of
placental insufficiency had poorer neurobehavioral competencies, which suggests delayed neurologic maturation.
Cont
Retarded growth: With placental causes of IUGR, catch-up
growth occurs after birth, but these patients usually remain smaller than expected.
Fetal programming of
cardiovascular disease: Recent studies implicate IUGR with adult onset of hypertension, coronary heart disease, hypercholesterolemia, and diabetes. These studies suggest that IUGR
Complications
A. Hypoxia:
1. Perinatal asphyxia. IUGR infants frequently have
birth asphyxia because they tolerate the stress of labor poorly. IUGR accounts for a large proportion of stillborn infants with hypoxia in utero.
2.
3.
B. Hypothermia.
Thermoregulation is compromised in IUGR
infants because of diminished subcutaneous fat insulation. Infants with IUGR secondary to fetal malnutrition late in gestation tend to be scrawny as a result of loss of subcutaneous fat. They tend to be more alert than their premature counterparts.
C.
Metabolic:
1. Hypoglycemia.
Carbohydrate metabolism is seriously disturbed, and
IUGR infants are highly susceptible to hypoglycemia as a consequence of diminished glycogen reserves and decreased capacity for gluconeogenesis. Oxidation of free fatty acids and triglycerides is reduced in IUGR infants, which limits alternate fuel sources. Hyperinsulinism, excess sensitivity to insulin deficient catecholamine release during hypoglycemia suggest abnormality of counterregulatory hormone mechanisms during periods of hypoglycemia in IUGR infants. Hypothermia may potentiate the problem of hypoglycemia.
2. Hyperglycemia. Very low birth weight infants have low insulin secretion, resulting in hyperglycemia.
D. Hematologic disorders:
Hyperviscosity and polycythemia may result from
increased erythropoietin levels secondary to fetal hypoxia associated with IUGR. Thrombocytopenia, neutropenia, and altered coagulation profile are also seen in IUGR infants. Polycythemia may also contribute to hypoglycemia and lead to cerebral injury.
E. Altered immunity. IUGR infants have decreased IgG levels. In addition, the thymus is reduced in size by 50% and peripheral blood lymphocytes are decreased.
Management
IUGR has many causes, therefore, there is not one treatment that always works.
Treatment
Although there are many causes of IUGR, the treatment
consists of either delivery or remaining in utero and improving blood flow to the uterus.
baby is otherwise healthy, early diagnosis and treatment of the problem may reduce the chance of a serious outcome.
babies who are at or near term have the best outcome if delivered promptly.
Cont
A. History of risk factors. The presence of maternal risk factors should alert the obstetrician to the likelihood of fetal growth retardation. Ultrasonography confirms the diagnosis. Correctable causes of impaired fetal growth warrant immediate attention. B. Delivery and resuscitation.
Appropriate timing of delivery is important. Delivery is usually
undertaken when the lungs are mature or when biophysical data obtained by monitoring reveal fetal distress. Labor is particularly stressful to IUGR fetuses. Skilled resuscitation should be available because birth asphyxia is common.
essential for all IUGR infants. Hypoglycemia should be treated promptly with parenteral dextrose and early feeding
E. Hematologic disorders. A central
congenital malformations or signs of congenital infections. Many intrauterine infections are clinically silent, and screening for these should be done routinely in IUGR infants.
G. Genetic anomalies. Screening for