Professional Documents
Culture Documents
Antidepressants
and Antipsychotics
• Anxiety
• Grief
• Depression
Psychosis
• A major emotional disorder that impairs the mental
function of the affected individual to the point that
the individual cannot participate in everyday life.
• Hallmark: loss of contact with reality
Affective Disorders
• Major emotional disorders that impair the
mental function of the affected individual to
the point that the individual cannot
participate in everyday life.
Affective Disorders
• Mania: abnormally pronounced emotions
• Depression: abnormally reduced emotions
• Bipolar affective disorder: exhibits both mania
and depression
Pathophysiology
Biochemical Imbalance
• Mental disorders are associated with abnormal
levels of endogenous chemicals, such as
neurotransmitters, in the brain.
Pathophysiology
Biochemical Imbalance
• Brain levels of certain catecholamines play an
important role in maintaining mental health.
– Dopamine
– Serotonin
– Histamine
Pathophysiology
Biochemical Imbalance
• Other biochemicals are necessary for normal
mental function.
– GABA
– acetylcholine
– lithium
Drug Categories
• Antidepressants
• tricyclics, tetracyclics, SSRIs, MAOIs
• Antimanic Agents
• lithium
Cyclic antidepressants
– tricyclics
– tetracyclics
• Monoamine oxidase inhibitors (MAOIs)
• Second-generation antidepressants
and SSRIs
• Tricyclic antidepressants—primary:
amitriptyline (Elavil), doxepin (Sinequan),
imipramine (Tofranil)
• Tricyclic antidepressants—secondary:
desipramine (Norpramin), nortriptyline
(Aventyl), protriptyline (Vivactil)
• Tetracyclic antidepressants:
amoxapine (Asendin), maprotiline (Ludiomil)
Blockade of serotonin:
– antidepressant, nausea, headache, anxiety,
sexual dysfunction
• phenelzine (Nardil)
• tranylcypromine (Parnate)
• isocarboxazid (Marplan)
• Newer
• Fewer side effects than tricyclics, but not
superior in overall efficacy or onset of action
– trazodone (Desyrel)
– bupropion (Wellbutrin, Zyban)
– selective serotonin reuptake inhibitors (SSRIs)